Jennifer Nachbur, ‘May’s Study Finds Connection between Chronic Pain and Anxiety Disorders’, http://www.uvm.edu/medicine/?Page=news&storyID=23304&category=spot1,  The University of Vermont (08-31-2016).

Hand-in-hand

Chronic pain and anxiety-related disorders frequently go hand-in-hand. (…) Increased expression of PACAP – a peptide neurotransmitter the body releases in response to stress – is also increased in response to neuropathic pain. (…) The anxious behavior and pain hypersensitivity were significantly reduced when a PACAP receptor antagonist – designed to block the response – was applied. (…) By targeting this regulator and pathway, we have opportunities to block both chronic pain and anxiety disorders.